One of the big advantages of 2/1 is that it's simpler than standard american. You don't need nearly as much discussion to determine which auctions are forcing, or to make out a playable (if hardly superior) convention card. This may seem counterintuitive in the US where "2/1" is taught as an "expert system" and most people learn "standard" first and then "graduate" from it -- but standard as played by beginners is not really a playable system at all. For this reason, 2/1 is the obvious system of choice for expert pickup partnerships, for experts playing with students, and so forth. The fact that most expert players have spent a lot of time playing in these situations (heck, even the most established expert partnership was an "expert pickup partnership" the first session they played) makes 2/1 an obvious favorite regardless of its relative merits.
In fact I seem to recall that Eddie Kantar and partner (using "standard" with a lot of agreements) trounced the expert field in a bidding competition back in the early days of 2/1 (like the late 1970s). Yet this did very little to slow 2/1 GF's surging popularity.

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